DDB Latina closed the year being named Network of the Year at Effies LATAM 2021. DDB Colombia was named Agency of the Year in LATAM with one Gold, seven Silvers, plus four Bronzes. Guatemala won four metals with four submissions that summarizes one Gold, two Silvers, and one Bronze.

TracyLocke Brazil made it to the winners list with one Gold for The Uniform that Never Existed, SunsetDDB Brazil won one silver and one bronze, ParadaisDDB Ecuador one silver and FahrenheitDDB Peru won two Silver and one Bronze.